Dr. Preetpal Singh Sidhu, PhD, NRCC, ASCP

Founder & Managing Member – Altus Capital AM LLC

The Story of Dr. Preetpal Singh Sidhu

Dr. Preetpal Singh Sidhu's story begins in Dhaban, Rajasthan, a village in northern India known for its close-knit rural culture and deep sense of community. Raised in a simple family with an agricultural background, he grew up surrounded by the values of hard work, humility, discipline, and resilience— qualities that would later define his journey as a scientist, entrepreneur, and CEO. From an early age, he learned to see limitations not as barriers, but as invitations to think bigger and work harder.

His academic path first took him to Bangalore, where he earned his bachelor's degree in Pharmacy. That period expanded his world: it exposed him to rigorous scientific training, sharpened his curiosity about medicine and drug discovery, and laid the technical foundation for everything that followed. It was in these formative years that his interest in the intersection of chemistry, health, and innovation truly began to take shape.

In 2007, Dr. Sidhu moved to the United States with a larger dream and a willingness to build a future from the ground up. He pursued a PhD in Medicinal Chemistry at Virginia Commonwealth University, where he immersed himself in advanced research and developed expertise in drug discovery and molecular science. The move marked more than a change in geography—it represented a defining leap of ambition, adaptation, and perseverance. In laboratories, classrooms, and research collaborations, he refined the scientific discipline that would become central to his professional identity.

That journey—from a small village in Rajasthan to advanced scientific research, entrepreneurship, and philanthropy in the United States—helps explain the leadership vision reflected in every business Dr. Sidhu has built. He has shaped his career by combining scientific depth with entrepreneurial courage, transforming education into innovation and innovation into meaningful impact. The accomplishments outlined below in diagnostics, investment, research, and philanthropy are not isolated achievements; they are chapters in a larger story of determination, continuous learning, and purpose-driven leadership.

Executive Summary

As the Founder and Managing Member of Altus Capital AM LLC, Dr. Preetpal Singh Sidhu leads a Kentucky-based alternative asset management firm focused on unlocking value through science-driven investment strategies, real estate acquisition, and venture development. He is also a pioneer in healthcare innovation as the founder of Solaris Diagnostics and Biopathogenix, and an active contributor to community well-being through his extensive philanthropic efforts.

Investment & Business Leadership

In 2022, Dr. Sidhu founded Altus Capital AM, bringing together his deep operational background with a forward-looking investment philosophy. The firm is committed to alternative asset classes with a particular interest in:

  • Specialty real estate development & management
  • Private equity in regulated industries: retail, entertainment, and hospitality
  • In parallel with his investment activities, Dr. Sidhu has led several real estate acquisition and development projects across Kentucky to Florida, focusing on strategic commercial and retail infrastructure. His dual role as a real estate investor and life sciences executive enables a unique understanding of the ecosystems that support biotech growth.

    In 2020, Dr. Sidhu co-founded Desi Capital a private lending company with a focus on retail operations: gas stations, liquor stores, event spaces, and social clubs.

    Healthcare Innovation

    Dr. Sidhu is the Founder of Solaris Diagnostics, a high-complexity, CLIA-certified laboratory in Nicholasville, KY, delivering state-of-the-art molecular diagnostics, toxicology, and infectious disease testing. His leadership ensures rigorous compliance, precision testing, and continuous innovation in diagnostics. He made a successful exit from Solaris in 2024.

    He is also the Founder of Biopathogenix, a biotechnology enterprise focused on developing advanced molecular tools for diagnostic and therapeutic applications. Biopathogenix reflects Dr. Sidhu’s dedication to expanding diagnostic capabilities and reducing healthcare disparities through innovation.

    Bioventures Capital was founded by Dr. Sidhu in 2025. It is a “ “ company that focuses on investing & commercializing early stage biotechnology and diagnostics start-ups.

    Academic Credentials & Scientific Impact

    Dr. Sidhu earned his PhD in Medicinal Chemistry from Virginia Commonwealth University, where he designed allosteric inhibitors of thrombin as part of his groundbreaking thesis research. He has held postdoctoral positions and research fellowships at:

  • Virginia Commonwealth University
  • University of Wisconsin–Milwaukee
  • Over the past two decades, Dr. Sidhu has made significant contributions to the field of clinical chemistry and drug discovery. His research has led to over 20 peer-reviewed publications covering:

  • Vitamin D receptor antagonists
  • Anticoagulant design
  • ADME profiling
  • Oncological pharmacology
  • He is board-certified in Clinical Chemistry (NRCC) and licensed as a Laboratory Director in multiple states, with additional certification as a Technologist in Chemistry (ASCP).

    Philanthropy & Community Engagement

    Dr. Sidhu is a steadfast advocate for community health and access. Through Solaris Diagnostics, he has led efforts to partner with regional health organizations, most notably donating incentives to blood donors during National Blood Donor Month to support the Kentucky Blood Center. In 2020 Dr. Sidhu facilitated over 1000 oxygen concentrators to be flown to India during the pandemic. He has supported various entities in Kentucky to recover flood damages. He also sponsors children’s underprivileged day cares.

    His philanthropic initiatives extend to:
  • Scholarship programs for underserved students in STEM fields
  • Public health education outreach in rural Kentucky communities
  • Support for early-stage minority entrepreneurs in healthcare
  • These efforts reflect his core belief that innovation and compassion must go hand in hand in building healthier, more equitable societies.

    Summary

    Dr. Preetpal Singh Sidhu’s career spans clinical excellence, entrepreneurial innovation, and strategic capital deployment. Whether in the laboratory, the boardroom, or the community, he brings an unwavering commitment to scientific integrity, impactful investment, and service to others. Through Altus Capital AM, Desi Capital, Solaris Diagnostics, and Biopathogenix, Dr. Sidhu is building a legacy defined by precision, purpose, and progress.

    Publications

  • Rational design of potent, small, synthetic allosteric inhibitors of thrombin
    Journal of medicinal chemistry, 2011/8/11
    Authors: Preetpal Singh Sidhu, Aiye Liang, Akul Y Mehta, May H Abdel Aziz, Qibing Zhou, Umesh R Desai
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  • Designing allosteric regulators of thrombin. Exosite 2 features multiple subsites that can be targeted by sulfated small molecules for inducing inhibition
    Journal of medicinal chemistry, 2013/6/27
    Authors: Preetpal Singh Sidhu, May H Abdel Aziz, Aurijit Sarkar, Akul Y Mehta, Qibing Zhou, Umesh R Desai
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  • First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa
    Bioorganic & medicinal chemistry letters, 2009/8/1
    Authors: Jenson Verghese, Aiye Liang, Preet Pal Singh Sidhu, Michael Hindle, Qibing Zhou, Umesh R Desai
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  • Identification of a novel, fast-acting GABAergic antidepressant
    Molecular psychiatry, 2018/2
    Authors:Katherine MJ McMurray, Marcia J Ramaker, Amanda M Barkley-Levenson, Preetpal S Sidhu, PK Elkin, M Kashi Reddy, Margaret L Guthrie, James M Cook, Viresh H Rawal, Leggy A Arnold, Stephanie C Dulawa, Abraham A Palmer
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  • Designing allosteric regulators of thrombin. Monosulfated benzofuran dimers selectively interact with Arg173 of exosite 2 to induce inhibition
    Journal of medicinal chemistry, 2012/8/9
    Authors: May H Abdel Aziz, Preetpal Singh Sidhu, Aiye Liang, Ji Yeong Kim, Philip D Mosier, Qibing Zhou, David H Farrell, Umesh R Desai
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  • Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor
    Biochemistry, 2013/6/18
    Authors: Premchendar Nandhikonda, Adam Yasgar, Athena M Baranowski, Preetpal S Sidhu, Megan M McCallum, Alan J Pawlak, Kelly Teske, Belaynesh Feleke, Nina Y Yuan, Chinedum Kevin, Daniel D Bikle, Steven D Ayers, Paul Webb, Ganesha Rai, Anton Simeonov, Ajit Jadhav, David Maloney, Leggy A Arnold
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  • 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di-and polyhydroxylated flavones in kidney mesangial cells
    PLoS One, 2015/3/19
    Authors: Xing Wang, Zhiwei Wang, Preetpal Singh Sidhu, Umesh R Desai, Qibing Zhou
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  • Anticancer activity of VDR-coregulator inhibitor PS121912
    JCancer chemotherapy and pharmacology, 2014/10
    Authors: Preetpal S Sidhu, Kelly Teske, Belaynesh Feleke, Nina Y Yuan, Margaret L Guthrie, Grant B Fernstrum, Nishita D Vyas, Lanlan Han, Joshua Preston, Jonathan W Bogart, Nicholas R Silvaggi, James M Cook, Rakesh K Singh, Daniel D Bikle, Leggy A Arnold
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  • Development of novel vitamin D receptor–coactivator inhibitors
    ACS medicinal chemistry letters, 2014/2/13
    Authors: Preetpal S Sidhu, Nicholas Nassif, Megan M McCallum, Kelly Teske, Belaynesh Feleke, Nina Y Yuan, Premchendar Nandhikonda, James M Cook, Rakesh K Singh, Daniel D Bikle, Leggy A Arnold
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  • Glo1 inhibitors for neuropsychiatric and anti-epileptic drug development
    Biochemical Society Transactions, 2014/4/1
    Authors: Katherine MJ McMurray, Margaret G Distler, Preetpal S Sidhu, James M Cook, Leggy A Arnold, Abraham A Palmer, Leigh D Plant
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  • On scaffold hopping: challenges in the discovery of sulfated small molecules as mimetics of glycosaminoglycans
    Bioorganic & medicinal chemistry letters, 2013/1/1
    Authors: Preetpal S Sidhu, Philip D Mosier, Qibing Zhou, Umesh R Desai
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  • Genetic and pharmacological manipulation of glyoxalase 1 regulates voluntary ethanol consumption in mice
    Addiction biology, 2017/3
    Authors: Katherine MJ McMurray, Preetpal S Sidhu, James M Cook, Leggy A Arnold, Abraham A Palmer
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  • PT19c, Another Nonhypercalcemic Vitamin D2 Derivative, Demonstrates Antitumor Efficacy in Epithelial Ovarian and Endometrial Cancer Models
    Genes & Cancer, 2013/11
    Authors: Nada Kawar, Shannon Maclaughlan, Timothy C Horan, Alper Uzun, Thilo S Lange, Kyu K Kim, Russell Hopson, Ajay P Singh, Preetpal S Sidhu, Kyle A Glass, Sunil Shaw, James F Padbury, Nicholi Vorsa, Leggy A Arnold, Richard G Moore, Laurent Brard, Rakesh K Singh
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  • Identification of VDR antagonists among nuclear receptor ligands using virtual screening
    Nuclear receptor research, 2014
    Authors: Kelly Teske, Premchendar Nandhikonda, Jonathan W Bogart, Belaynesh Feleke, Preetpal Sidhu, Nina Yuan, Joshua Preston, Robin Goy, Lanlan Han, Nicholas R Silvaggi, Rakesh K Singh, Daniel D Bikle, James M Cook, Leggy A Arnold
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  • Antitumor activity of 3-indolylmethanamines 31B and PS121912
    Anticancer research, 2015/11/1
    Authors: Margaret L Guthrie, Preetpal S Sidhu, Emily K Hill, Timothy C Horan, Premchendar Nandhikonda, Kelly A Teske, Nina Y Yuan, Marina Sidorko, Revathi Rodali, James M Cook, Lanlan Han, Nicholas R Silvaggi, Daniel D Bikle, Richard G Moore, Rakesh K Singh, Leggy A Arnold
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  • Modulation of Transcription mediated by the Vitamin D Receptor and the Peroxisome Proliferator-Activated Receptor δ in the presence of GW0742 analogs
    Journal of biomolecular research & therapeutics, 2014/2/10
    Authors: Kelly Teske, Premchendar Nandhikonda, Jonathan W Bogart, Belaynesh Feleke, Preetpal Sidhu, Nina Yuan, Joshua Preston, Robin Goy, Leggy A Arnold
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  • Direct N-sec-alkylation of amides by reaction of α-halohydroxamates and sulfonylindoles: an approach to 3-indolyl methanamines
    Journal of medicinal chemistry, 2013/6/27
    Authors: Preetpal Singh Sidhu, May H Abdel Aziz, Aurijit Sarkar, Akul Y Mehta, Qibing Zhou, Umesh R Desai
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  • One-pot synthesis protocol for highly functionalized benzofuran scaffold
    Postdoc J, 2013
    Authors: Preetpal Singh Sidhu
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  • Parallel chemistry approach to identify novel nuclear receptor ligands based on the GW0742 scaffold
    ACS combinatorial science, 2017/10/9
    Authors: Kelly A Teske, Ganesha Rai, Premchendar Nandhikonda, Preetpal S Sidhu, Belaynesh Feleke, Anton Simeonov, Adam Yasgar, Ajit Jadhav, David J Maloney, Leggy A Arnold
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  • A simple, general approach of allosteric coagulation enzyme inhibition through monosulfated hydrophobic scaffolds
    Bioorganic & Medicinal Chemistry Letters, 2014/12/15
    Authors: Preetpal Singh Sidhu, Qibing Zhou, Umesh R Desai
  • Allosteric regulation of dual function of thrombin
    J Pharm Pharmacol, 2013
    Authors: Preetpal Singh Sidhu
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  • Allosteric inhibitors of thrombin
    Journal of Postdoctoral Research November, 2013/6/27
    Authors: Preetpal S Sidhu
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  • Designing allosteric inhibitors of thrombin
    Journal of medicinal chemistry, 2011
    Authors: Preetpal Singh Sidhu
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  • Discovery of Selective vitamin D Receptor Coregulator Inhibitor
    Journal of Postdoctoral Research April 2014
    Authors:Preetpal S Sidhu
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  • QSAR Study of Thiophene-Anthranilamides Based Factor Xa Direct Inhibitors
    Journal of Postdoctoral Research March, 2014
    Authors: Preetpal S Sidhu
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  • AN OPTIMIZED SYNTHETIC PROTOCOL FOR BIOLOGICALLY RELEVANT, HIGHLY FUNCTIONALIZED BENZOFURANS
    International Journal of Pharmaceutical Sciences and Research, 2014/1/1
    Authors: Preetpal Singh Sidhu
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  • Discovery and development of dabigatran
    Journal of Postdoctoral Research January
    Authors: Preetpal Singh Sidhu
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    Patents

  • Vitamin D receptor-coregulator inhibitors
    Journal of medicinal chemistry, 2016/8/16
    Authors: Alexander E Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K Singh
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  • Vitamin d receptor-coregulator inhibitors
    Journal of medicinal chemistry, 2018/12/20
    Authors: Alexander E Arnold, Preetpal Singh Sidhu, Premchendar Nandhikonda, Rakesh K Singh
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